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"Science Revives Extinct Dire Wolves"

Author:Kristen Update:Apr 18,2025

Bringing a super-sized canine back from extinction after 12,500 years might sound like the plot of a thrilling sci-fi movie, but it's a reality thanks to the biotech company Colossal Biosciences. They've successfully brought three dire wolves into existence, now residing in a secret location in the US. These majestic creatures, named Romulus, Remus, and Khaleesi, were created using the DNA of the common gray wolf, gene-editing techniques, and domestic dog surrogates.

Romulus and Remus at three months old

Colossal Biosciences, driven by a passion that echoes the spirit of "Game of Thrones," has achieved what many might consider a feat of science fiction. CEO Ben Lamm expressed immense pride in the team's accomplishment, stating, "This massive milestone is the first of many coming examples demonstrating that our end-to-end de-extinction technology stack works."

The process involved extracting DNA from a 13,000-year-old tooth and a 72,000-year-old skull to produce healthy dire wolf puppies. Lamm emphasized the magical nature of their technology, quoting, "any sufficiently advanced technology is indistinguishable from magic." This breakthrough not only showcases the potential of genetic engineering but also underscores its broader impact on conservation efforts.

Romulus and Remus at one month old

Colossal Biosciences is no stranger to groundbreaking projects. They previously engineered a Colossal Woolly Mouse, which resembles a mammoth, using computational analysis of 59 woolly, Columbian, and steppe mammoth genomes. However, the company's work has faced criticism, with some arguing that the dire wolves are essentially normal wolves in a costume, due to the limited availability of viable dire wolf DNA.

The company's motives extend beyond creating sensational news and owning extraordinary pets. Colossal Biosciences aims to use its findings to aid in the preservation of current species for future generations. Dr. Christopher Mason, a scientific advisor and board member, highlighted the transformative nature of their work, saying, "The de-extinction of the dire wolf and an end-to-end system for de-extinction is transformative and heralds an entirely new era of human stewardship of life."

The technologies developed to revive the dire wolf could also play a crucial role in saving other endangered animals. Mason praised the technological advancements, noting, "This is an extraordinary technological leap in genetic engineering efforts for both science and for conservation as well as preservation of life, and a wonderful example of the power of biotechnology to protect species, both extant and extinct."

For the dire wolves, Colossal Biosciences has collaborated with the American Humane Society and the USDA to ensure their well-being in a 2,000+ acre preserve. These remarkable animals are cared for by a dedicated team, ensuring they thrive in their new environment.